期刊
CHEMSUSCHEM
卷 13, 期 14, 页码 3594-3598出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cssc.202001068
关键词
3-acetamido-5-acetylfuran; aluminum catalysis; biomass valorization; homogeneous catalysis; N-acetylglucosamine dehydration
资金
- Japan Science and Technology Agency (JST) ALCA [JPMJAL1309, 18H01781]
- Japan Society for the Promotion of Science (JSPS)
- Grants-in-Aid for Scientific Research [18H01781] Funding Source: KAKEN
3-Acetamido-5-acetylfuran (3A5AF) is a promising intermediate obtained from chitin for the production of N-containing value-added chemicals. However, the synthetic method is complicated so far, which has limited further investigation using 3A5AF. Herein, a facile method was developed for synthesizing 3A5AF from N-acetyl-d-glucosamine (NAG), including a simple isolation procedure. A 30 % yield of 3A5AF was obtained by performing the dehydration of NAG in N,N-dimethylformamide (DMF) solvent in the presence of AlCl3.6 H2O at a temperature as low as 120 degrees C by conventional heating for 30 min. This method tolerated a wide range of temperature and concentration of substrate, thus easily allowing scale-up of the reaction. The produced 3A5AF was isolated with 98 % purity by simple column chromatography. Additionally, a highly functionalized N-containing lactone was identified as a byproduct under these reaction conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据