期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 15, 期 14, 页码 2076-2091出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202000493
关键词
lanthanide nanoprobes; near-infrared bioimaging; upconversion; downconversion; photoacoustic; lifetime
资金
- MOE [2017-T2-2-110]
- A*Star SERC [A1983c0028 (M4070319)]
- National Natural Science Foundation of China (NSFC) [51929201]
- [RG5/18 (S)]
- [SPMS-M4082042.110]
Optical imaging plays a growing role in modern biomedical research and clinical applications due to its high sensitivity, superb spatiotemporal resolution and minimal hazards. Lanthanide-doped nanoparticles (LDNPs), as a classical category of luminescent materials, exhibit promising photostability, near-infrared (NIR)-excited frequency up-/down-converting capabilities, emission fine-tuning and multispectral features, which have greatly promoted the endeavors of deeper and clearer diagnostics in complex living conditions. This review focuses on the recent advances of LDNP-based multipurpose imaging studies using upconversion, downshifting, lifetime, photoacoustic and multimodal nanoprobes in the NIR (650-1000 nm) and the second near-infrared window (NIR-II, 1000-1700 nm). The principle and design of various functional, activatable, multiplexing or multimodal lanthanide-imaging nanoprobes (LINPs) as well as representative biophotonic applications are summarized in detail. In addition, the future perspectives and challenges for facilitating LINPs to clinical translations are discussed.
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