期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 30, 页码 6784-6788出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202001439
关键词
anilines; ortho-substitution; perfluoroalkylation; Ru catalyst; site-selectivity
资金
- BMBF
- State of Mecklenburg-Western Pomerania, Germany
- Chinese Scholarship Council, China
Introducing (per)fluoroalkyl groups into arenes continues to be an interesting, but challenging area in organofluorine chemistry. We herein report an ortho-selective C-H perfluoroalkylation including trifluoromethylations of anilines and indoles without the need of protecting groups using RfI and RfBr as commercially available reagents. The availability and price of the starting materials and the inherent selectivity make this novel methodology attractive for the synthesis of diverse (per)fluoroalkylated building blocks, for example, for bioactive compounds and materials.
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