期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 61, 页码 13783-13787出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202002533
关键词
amidyl radicals; EDA complexes; lactams; radical additions to allenes; vinyl radicals
资金
- NIH [R01 GM11412, 1S10 OD020022-1, S10 OK012245]
- NSF [CHE-1048642, CHE-0342998]
- University of Wisconsin-Madison
The addition of radicals to unsaturated precursors is a powerful tool for the synthesis of both carbo- and heterocyclic organic building blocks. The recent advent of mild ways to generate N-centered radicals has reignited interest in exploiting highly regio-, chemo-, and stereoselective transformations that employ these reactive intermediates. While the additions of aminyl, iminyl, and amidyl radicals to alkenes and alkynes have been well-studied, analogous additions to allenes are scarce. Allenes offer several attractive features, including potential for selective amidation at three distinct sites via judicious choice of precursor or radical source, the opportunity for axial-to-point chirality transfer, and productive trapping of vinyl or allyl radical intermediates to diversify functionality in the products. In this article, we report a regioselective addition of amidyl radicals to allenes to furnish an array of valuable N-heterocycle scaffolds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据