期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 54, 页码 12333-12337出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202001816
关键词
benzothiophene; C-F activation; fluorine; ketone; thioxanthone
资金
- JSPS KAKENHI [JP19K05451, JP18H02104, JP18H04386, 19J14128]
- Naito Foundation
- Japan Agency for Medical Research and Development (AMED) [JP19am0101098, JP19gm0910007]
- Cooperative Research Project of Research Center for Biomedical Engineering
- Grants-in-Aid for Scientific Research [19J14128] Funding Source: KAKEN
An efficient synthetic method of aromatic ketones through C-F cleavage of trifluoromethyl group is disclosed. The high functional group tolerance of the transformation and the remarkable stability of trifluoromethyl group in various reactions enabled multi-substituted aromatic ketone synthesis in an efficient route involving useful transformations such asortho-lithiation, aryne chemistry, and cross-couplings.
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