4.6 Review

Steering Site-Selectivity in Transition Metal-Catalyzed C-H Bond Functionalization: the Challenge of Benzanilides

期刊

CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 44, 页码 9688-9709

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202000672

关键词

anilide; benzamide; C-H functionalization; homogeneous catalysis; transition metals

资金

  1. COST Action (CHAOS) [CA15106]

向作者/读者索取更多资源

Selective C-H bond functionalization catalyzed by metal complexes have completely revolutionized the way in which chemical synthesis is conceived nowadays. Typically, the reactivity of a transition metal catalyst is the key to control the site-, regio- and/or stereo-selectivity of a C-H bond functionalization. Of particular interests are molecules that contain multiple C-H bonds prone to undergo C-H bond activations with very similar bond dissociation energies at different positions. This is the case of benzanilides, relevant chemical motifs that are found in many useful fine chemicals, in which two C-H sites are present in chemically different aromatic fragments. In the last years, it has been found that depending on the metal catalyst and the reaction conditions, the amide motif might behave as a directing group towards the metal-catalyzed C-H bond activation in the benzamide site or in the anilide site. The impact and the consequences of such subtle control of site-selectivity are herein reviewed with important applications in carbon-carbon and carbon-heteroatom bond forming processes. The mechanisms unraveling these unique transformations are discussed in order to provide a better understanding for future developments in the field of site-selective C-H bond functionalization with transition metal catalysts.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据