期刊
CELL AND TISSUE RESEARCH
卷 368, 期 2, 页码 229-238出版社
SPRINGER
DOI: 10.1007/s00441-016-2462-2
关键词
Mesenchymal stem cells; microRNAs; Osteogenesis; Transcription factors; Signaling pathways
类别
资金
- National Natural Science Foundation of China [31272425, 31472075]
- National Science and Technology Pillar Program [2011BAD28B01]
- Major Technology Innovation Program of Hubei Province [2014ABA025]
Mesenchymal stem cells (MSCs), also referred to as multipotent stromal cells, have been isolated from various adult tissue sources because of their capabilities of differentiating into multiple cell lineages including osteoblasts, thus providing a novel approach for treating bone diseases and metabolic disorders. Despite extensive potential in cell therapy and widespread interest in clinical applications of MSCs, the molecular mechanisms with regard to the regulation of their therapeutic properties and osteoblast differentiation remain to be fully elucidated. MicroRNAs (miRNAs), a novel class of endogenous small noncoding RNAs, regulate gene expressions by translational repression or degradation of their targets. Recently, emerging evidence has shown that miRNAs are closely involved in controlling the key steps of osteoblast differentiation in MSCs. This review focuses on miRNAs and their roles in regulating osteogenic differentiation of MSCs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据