期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 50, 页码 11558-11564出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202001368
关键词
cyanation; DFT study; H-bonded template; para-C-H activation; regioselectivity
资金
- SERB India [CRG/2018/003951]
- National Natural Science Foundation of China [21973055]
- Natural Science Foundation of Shandong Province [ZR2019MB049]
- IITB-Monash Research Academy
- CSIR-India
- UGC
- DST-India [YSS/2014/000530]
The significance of site selective functionalization stands upon the superior selectivity, easy synthesis and diverse product utility. In this work, we demonstrate thepara-selective introduction of versatile nitrile moiety, enabled by a detachable and reusable H-bonded auxiliary. The methodology holds its efficiency irrespective of substrate electronic bias. The conspicuous shift in the step energetics was probed by both experimental and computational mechanistic tools, which heralds the inception ofpara-deuteration. The synthetic impact of the methodology was highlighted with reusability of directing group and post synthetic modifications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据