期刊
CHEMICAL REVIEWS
卷 120, 期 8, 页码 3852-3889出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.9b00739
关键词
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资金
- National Natural Science Foundation of China [21974075, 21675093]
- Taishan Scholar Program of Shandong Province of China [ts20110829]
- Shandong Provincial Natural Science Foundation [ZR2019MB039]
- Shandong Key Laboratory of Biochemical Analysis [SKLBA1905]
- Doctoral Research Initiation Project of Taishan University [Y-01-2018018]
- EPSRC
- CRUK
- Royal Society
- Weston Foundation
- Osler Diagnostics
The ability to fabricate sensory systems capable of highly selective operation in complex fluid will undoubtedly underpin key future developments in healthcare. However, the abundance of (bio)molecules in these samples can significantly impede performance at the transducing interface where nonspecific adsorption (fouling) can both block specific signal (reducing sensitivity) and greatly reduce assay specificity. Herein, we aim to provide a comprehensive review discussing concepts and recent advances in the construction of antifouling sensors that are, through the use of chemical, physical, or biological engineering, capable of operating in complex sample matrix (e.g., serum). We specifically highlight a range of molecular approaches to the construction of solid sensory interfaces (planar and nanoparticulate) and their characterization and performance in diverse in vitro and in vivo analyte (e.g., proteins, nucleic acids, cells, neuronal transmitters) detection applications via derived selective optical or electrochemical strategies. We specifically highlight those sensors that are capable of detection in complex media or those based on novel architectures/approaches. Finally, we provide perspectives on future developments in this rapidly evolving field.
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