期刊
CELL
卷 164, 期 4, 页码 681-694出版社
CELL PRESS
DOI: 10.1016/j.cell.2015.12.034
关键词
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资金
- National Institutes of Health [R01 CA157996, CA157996-04S1, P50 CA70907, P41 EB015908, UL1 TR001105]
- Welch Foundation [I-1733]
- CPRIT [R-1107-02, RP130272]
- Canadian Institutes of Health Research [MFE 140911]
- V Foundation
Non-small cell lung cancer (NSCLC) is heterogeneous in the genetic and environmental parameters that influence cell metabolism in culture. Here, we assessed the impact of these factors on human NSCLC metabolism in vivo using intraoperative 13 C-glucose infusions in nine NSCLC patients to compare metabolism between tumors and benign lung. While enhanced glycolysis and glucose oxidation were common among these tumors, we observed evidence for oxidation of multiple nutrients in each of them, including lactate as a potential carbon source. Moreover, metabolically heterogeneous regions were identified within and between tumors, and surprisingly, our data suggested potential contributions of non-glucose nutrients in well-perfused tumor areas. Our findings not only demonstrate the heterogeneity in tumor metabolism in vivo but also highlight the strong influence of the microenvironment on this feature.
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