期刊
CELL
卷 167, 期 3, 页码 789-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2016.10.003
关键词
-
资金
- National Research Foundation of Korea (NRF) - Korean government [2016R1C1B2008776, 2016R1A4A1011189]
- National Institute of General Medical Sciences [5UO1-GM107623-02]
- National Research Foundation of Korea [2016R1A4A1011189, 2016R1C1B2008776] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Two complementary approaches were used in search of the intracellular targets of the toxic PR poly-dipeptide encoded by the repeat sequences expanded in the C9orf72 form of amyotrophic lateral sclerosis. The top categories of PRn-bound proteins include constituents of non-membrane invested cellular organelles and intermediate filaments. PRn targets are enriched for the inclusion of low complexity (LC) sequences. Evidence is presented indicating that LC sequences represent the direct target of PRn binding and that interaction between the PRn poly-dipeptide and LC domains is polymer-dependent. These studies indicate that PRn-mediated toxicity may result from broad impediments to the dynamics of cell structure and information flow from gene to message to protein.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据