期刊
CHEMICAL ENGINEERING JOURNAL
卷 385, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2019.123959
关键词
NIR-II imaging; Rare-earth doped nanoparticles; Cancer cell membrane; Tumor imaging; Surgery navigation
资金
- Office of Science (BER), US Department of Energy [DE-SC0008397]
- National Natural Science Foundation of China [81630049, 81801738, 81901783, 81571747, 81371628]
- National Science and Technology Support Program [2015BAI01B09]
- China Scholarship Council [201706160068]
With the attractive characteristics of low toxicity, narrow emission spectra, long fluorescence lifetime, and no photobleaching, rare-earth doped nanoparticles (RENPs) have become promising imaging nanoplatforms in the second near-infrared window (NIR-II, 1000-1700 nm). Many studies have been devoted to different surface modification strategies of RENPs to achieve good NIR-II tumor imaging property. However, the tumor imaging efficiency of these approaches remains disappointing. Herein, two methods were pursued to modify RENPs with either polyethylene glycol (PEG) or cancer-cell-membrane to generate PEGylated-RENPs and cancer-cell-membrane camouflaged RENPs (CC-RENPs), respectively. This study demonstrated that cancer-cell-membrane coating of RENPs greatly improved tumor imaging performance in NIR-II window than PEG coating. Besides, CC-RENPs uptakes in liver and spleen significantly decreased. Importantly, CC-RENPs was found to be capable to aid us to pursue precise resection of the tumor. In conclusion, CC-RENPs are capable of targeting tumors and show high tumor NIR-II imaging quality. They are highly promising nanomaterials for future medical applications.
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