期刊
CELL
卷 166, 期 3, 页码 555-566出版社
CELL PRESS
DOI: 10.1016/j.cell.2016.07.002
关键词
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资金
- American Cancer Society [127097-PF-14-255-01-TBE]
- American Heart Association [15POST25560077]
- Ludwig Center at Harvard
- Paul F. Glenn Foundation
- National Institute of Diabetes and Digestive and Kidney Diseases [1R01DK103295-01A1]
Mitochondria are bioenergetic, biosynthetic, and signaling organelles that are integral in stress sensing to allow for cellular adaptation to the environment. Therefore, it is not surprising that mitochondria are important mediators of tumorigenesis, as this process requires flexibility to adapt to cellular and environmental alterations in addition to cancer treatments. Multiple aspects of mitochondrial biology beyond bioenergetics support transformation, including mitochondrial biogenesis and turnover, fission and fusion dynamics, cell death susceptibility, oxidative stress regulation, metabolism, and signaling. Thus, understanding mechanisms of mitochondrial function during tumorigenesis will be critical for the next generation of cancer therapeutics.
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