期刊
CELL
卷 166, 期 6, 页码 1411-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2016.08.050
关键词
-
资金
- NIH [R01 AI21144, GM49985, GM36659, P41 GM103481, S10RR028096]
- Human Frontier Science Program long-term fellowship [LT00160]
- National Science Foundation through partnership in the BioXFEL Science Technology Center [NSF-1231306]
- [S10D016229]
A complete, 52-protein, 2.5 million dalton, Mediator-RNA polymerase II pre-initiation complex (Med-PIC) was assembled and analyzed by cryo-electron microscopy and by chemical cross-linking and mass spectrometry. The resulting complete Med-PIC structure reveals two components of functional significance, absent from previous structures, a protein kinase complex and the Mediator-activator interaction region. It thereby shows how the kinase and its target, the C-terminal domain of the polymerase, control Med-PIC interaction and transcription.
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