Metal-Organic Frameworks: A New Platform for Enzyme Immobilization

Metal-organic frameworks (MOFs) with attractive properties such as high surface area, tunable porosity, designable functionality and excellent stability, have aroused great interest from researchers as the matrices for enzyme immobilization. Recently, several efficient strategies including surface immobilization, post-synthetic infiltration and in situ encapsulation have been explored. MOF-immobilized enzymes, named enzymes@MOFs, show remarkably enhanced stability and recyclability, accelerating cell-free biocatalysis in diverse applications. This concept will impart the typical strategies for enzyme immobilization with MOFs, and their potential applications.