期刊
CHEMBIOCHEM
卷 21, 期 14, 页码 1947-1954出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.202000092
关键词
Cysteine; cystine; disulfide bridges; reducing agents; solid-phase peptide synthesis
资金
- National Research Foundation (NRF)
- MINECO [RTI2018-093831-B-100]
- Generalitat de Catalunya (Spain) [2017 SGR 1439]
- University of KwaZulu-Natal
Cysteine is present in a large number of natural and synthetic (bio)molecules. Although the thiol side chain of Cys can be in a free form, in most cases it forms a disulfide bond either with a second Cys (bridge) or with another thiol, as in the case of protecting groups. Efficient reduction of these disulfide bridges is a requirement for many applications of Cys-containing molecules in the fields of chemistry and biochemistry. Here we review reducing methods for disulfide bonds, taking into consideration the solubility of the substrates when selecting the appropriate reducing reagent.
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