期刊
CELL
卷 164, 期 6, 页码 1198-1211出版社
CELL PRESS
DOI: 10.1016/j.cell.2016.02.048
关键词
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资金
- National Institutes of Health [R37 AI034206, F30 AI122721]
- National Institutes of Health (MSTP grant) [T32 GM07739]
- Ludwig Cancer Center at Memorial Sloan-Kettering Cancer Center
- Hilton Foundation
- Howard Hughes Medical Institute
Although they are classically viewed as continuously recirculating through the lymphoid organs and blood, lymphocytes also establish residency in non-lymphoid tissues, most prominently at barrier sites, including the mucosal surfaces and skin. These specialized tissue-resident lymphocyte subsets span the innate-adaptive continuum and include innate lymphoid cells (ILCs), unconventional T cells (e.g., NKT, MAIT, gamma delta T cells, and CD8 alpha alpha(+) IELs), and tissue-resident memory T (T-RM) cells. Although these diverse cell types differ in the particulars of their biology, they nonetheless exhibit important shared features, including a role in the preservation of tissue integrity and function during homeostasis, infection, and non-infectious perturbations. In this Review, we discuss the hallmarks of tissue-resident innate, innate-like, and adaptive lymphocytes, as well as their potential functions in non-lymphoid organs.
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