期刊
CELL
卷 164, 期 6, 页码 1185-1197出版社
CELL PRESS
DOI: 10.1016/j.cell.2016.02.004
关键词
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资金
- Novo Nordisk Foundation
- Knut and Alice Wallenberg Foundation
- Vetenskapsradet
- FORMAS
- Joint Bio-Energy Institute - US Department of Energy, Office of Science, Office of Biological and Environmental Research [DE-AC02-05CH11231]
- Synthetic Biology Engineering Research Center (SynBERC) through National Science Foundation [NSF EEC 0540879]
- NNF Center for Biosustainability [Synthetic Biology Tools for Yeast, Yeast Cell Factories] Funding Source: researchfish
- Novo Nordisk Fonden [NNF10CC1016517] Funding Source: researchfish
Metabolic engineering is the science of rewiring the metabolism of cells to enhance production of native metabolites or to endow cells with the ability to produce new products. The potential applications of such efforts are wide ranging, including the generation of fuels, chemicals, foods, feeds, and pharmaceuticals. However, making cells into efficient factories is challenging because cells have evolved robust metabolic networks with hard-wired, tightly regulated lines of communication between molecular pathways that resist efforts to divert resources. Here, we will review the current status and challenges of metabolic engineering and will discuss how new technologies can enable metabolic engineering to be scaled up to the industrial level, either by cutting off the lines of control for endogenous metabolism or by infiltrating the system with disruptive, heterologous pathways that overcome cellular regulation.
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