期刊
CELL
卷 167, 期 1, 页码 99-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2016.08.023
关键词
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资金
- SNSF Starting Grant [BSSGI0_155778]
- University of Basel
- Biozentrum Basel International PhD Program Fellowships for Excellence
- Swiss National Science Foundation (SNF) [BSSGI0_155778] Funding Source: Swiss National Science Foundation (SNF)
Bacterial type VI secretion system (T6SS) is a nano-machine that works similarly to a speargun. Rapid contraction of a sling (sheath) drives a long shaft (Hcp) with a sharp tip and associated effectors through the target cell membrane. We show that the amount and composition of the tip regulates initiation of full-length sheath assembly and low amount of available Hcp decreases sheath length. Importantly, we show that both tip and Hcp are exchanged by T6SS among by-standing cells within minutes of initial cell-cell contact. The translocated proteins are reused for new T6SS assemblies suggesting that tip and Hcp reach the cytosol of target cells. The efficiency of protein translocation depends on precise aiming of T6SS at the target cells. This inter-bacterial protein complementation can support T6SS activity in sister cells with blocked protein synthesis and also allows cooperation between strains to increase their potential to kill competition.
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