期刊
CEREBRAL CORTEX
卷 30, 期 7, 页码 4257-4268出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhaa053
关键词
brain development; cortical sulci; fetal brain; first folds; sulcal pattern
资金
- Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health (NIH) [R21HD094130, U01HD087211]
- National Institute of Biomedical Imaging and Bioengineering of the NIH [R01EB017337]
- National Institute of Neurological Disorders and Stroke of the NIH [K23NS101120]
- American Heart Association [19IPLOI34660336]
- Swiss National Science Foundation [P300PB_167804]
- Swiss National Science Foundation (SNF) [P300PB_167804] Funding Source: Swiss National Science Foundation (SNF)
Sulcal pits are thought to represent the first cortical folds of primary sulci during neurodevelopment. The uniform spatial distribution of sulcal pits across individuals is hypothesized to be predetermined by a human-specific protomap which is related to functional localization under genetic controls in early fetal life. Thus, it is important to characterize temporal and spatial patterns of sulcal pits in the fetal brain that would provide additional information of functional development of the human brain and crucial insights into abnormal cortical maturation. In this paper, we investigated temporal patterns of emergence and spatial distribution of sulcal pits using 48 typically developing fetal brains in the second half of gestation. We found that the position and spatial variance of sulcal pits in the fetal brain are similar to those in the adult brain, and they are also temporally uniform against dynamic brain growth during fetal life. Furthermore, timing of pit emergence shows a regionally diverse pattern that may be associated with the subdivisions of the protomap. Our findings suggest that sulcal pits in the fetal brain are useful anatomical landmarks containing detailed information of functional localization in early cortical development and maintaining their spatial distribution throughout the human lifetime.
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