期刊
CELL
卷 165, 期 6, 页码 1332-1345出版社
CELL PRESS
DOI: 10.1016/j.cell.2016.05.041
关键词
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资金
- Swedish Research Council
- NovoNordisk foundation
- Torsten Soderberg's foundation
- Swedish Heart Lung Foundation
- Goran Gustafsson's foundation
- IngaBritt och Arne Lund-bergs Foundation
- Knut and Alice Wallenberg Foundation
- FP7 sponsored program METACARDIS
- Region Vastra Gotaland
- Sahlgrenska University Hospital
- ERC Consolidator Grant (European Research Council) [615362-METABASE]
- EMBO [ALTF 1305-2014, GA-2013-609409]
- NNF Center for Basic Metabolic Research [Bäckhed Group] Funding Source: researchfish
- Novo Nordisk Fonden [NNF13OC0008163] Funding Source: researchfish
A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis? A growing body of work implicates microbially produced metabolites as crucial executors of diet-based microbial influence on the host. Here, we will review data supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs). SCFAs can directly activate G-coupled-receptors, inhibit histone deacetylases, and serve as energy substrates. They thus affect various physiological processes and may contribute to health and disease.
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