期刊
CELL
卷 166, 期 4, 页码 802-821出版社
CELL PRESS
DOI: 10.1016/j.cell.2016.07.031
关键词
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资金
- Ministerio de Economia y Competitividad, Instituto de Salud Carlos III, and Botin Foundation (Spain)
- Ministerio de Economia y Competitividad and Gobierno del Principado de Asturias (Spain)
- Fundacion Bancaria Caja de Ahorros de Asturias
- FWF grants LIPOTOX [I1000, P 27893, P24381-B20]
- BMWFW grant Unconventional research''
- Ligue contre le Cancer (equipe labelisee)
- Agence National de la Recherche (ANR) - Projets blancs
- ANR
- ERA-Net for Research on Rare Diseases
- Association pour la recherche sur le cancer (ARC)
- Canceropole Ile-de-France
- Institut National du Cancer (INCa)
- Institut Universitaire de France
- Fondation pour la Recherche Medicale (FRM)
- European Commission (ArtForce)
- European Research Council (ERC)
- LeDucq Foundation
- LabEx Immuno-Oncology
- SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
- Paris Alliance of Cancer Research Institutes (PACRI)
Several metabolic alterations accumulate over time along with a reduction in biological fitness, suggesting the existence of a metabolic clock'' that controls aging. Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence metabolism. Each of the nine hallmarks of aging is connected to undesirable metabolic alterations. The main features of the westernized'' lifestyle, including hypercaloric nutrition and sedentariness, can accelerate aging as they have detrimental metabolic consequences. Conversely, lifespan-extending maneuvers including caloric restriction impose beneficial pleiotropic effects on metabolism. The introduction of strategies that promote metabolic fitness may extend healthspan in humans.
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