Nicotinic Acetylcholine Receptors of PC12 Cells

Nicotinic acetylcholine receptors (nAChRs) have gained much attention in the scientific community since they play a significant role in multiple physiological and pathophysiological processes. Multiple approaches to study the receptors exist, with characterization of the receptors' functionality at a single cellular level using cell culturing being one of them. Derived from an adrenal medulla tumor, PC12 cells express nicotinic receptor subunits and form functional nicotinic receptors. Thus, the cells offer a convenient environment to address questions related to the functionality of the receptors. The review summarizes the findings on nicotinic receptors' expression and functions which were conducted using PC12 cells. Specific focus is given to alpha 3-containing receptors as well as alpha 7 receptor. Critical evaluation of findings is provided alongside insights into what can still be learned about nAChRs, using PC12 cells.

Automated summary

PC12 cells derived from adrenal medulla tumor are used to study nicotinic acetylcholine receptors, offering a convenient environment for research on receptor functionality. The review summarizes studies on receptor expression and function using PC12 cells, focusing on alpha 3-containing receptors and alpha 7 receptors. Critical evaluation of findings and insights into further research using PC12 cells are provided.