期刊
CELL
卷 167, 期 7, 页码 1788-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2016.11.041
关键词
-
资金
- German Research Foundation [Zo 287-4-1]
- National Institutes of Health [R01-GM090278, K99-GM115868-02]
More than 98% of the mammalian genome is non-coding, and interspersed transposable elements account for similar to 50% of noncoding space. Here, we demonstrate that a specific interaction between the polycomb protein EZH2 and RNA made from B2 SINE retrotransposons controls stress-responsive genes in mouse cells. In the heat-shock model, B2 RNA binds stress genes and suppresses their transcription. Upon stress, EZH2 is recruited and triggers cleavage of B2 RNA. B2 degradation in turn upregulates stress genes. Evidence indicates that B2 RNA operates as a speed bump'' against advancement of RNA polymerase II, and temperature stress releases the brakes on transcriptional elongation. These data attribute a new function to EZH2 that is independent of its histone methyltransferase activity and reconcile how EZH2 can be associated with both gene repression and activation. Our study reveals that EZH2 and B2 together control activation of a large network of genes involved in thermal stress.
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