期刊
CELL
卷 164, 期 5, 页码 859-871出版社
CELL PRESS
DOI: 10.1016/j.cell.2016.01.024
关键词
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资金
- Bill and Melinda Gates Foundation
- NIH [DK30292, DK70977, P30 AR057235]
- Office of Health, Infectious Diseases and Nutrition, Bureau for Global Health, USAID through the Food and Nutrition Technical Assistance II and III Projects (FANTA) [GHN-A-00-08-00001-00, AID-OAA-A-12-00005]
- Academy of Finland [252075]
- Medical Research Fund of Tampere University Hospital [9M004]
Identifying interventions that more effectively promote healthy growth of children with undernutrition is a pressing global health goal. Analysis of human milk oligosaccharides (HMOs) from 6-month-post-partum mothers in two Malawian birth cohorts revealed that sialylated HMOs are significantly less abundant in those with severely stunted infants. To explore this association, we colonized young germ-free mice with a consortium of bacterial strains cultured from the fecal microbiota of a 6-month-old stunted Malawian infant and fed recipient animals a prototypic Malawian diet with or without purified sialylated bovine milk oligosaccharides (S-BMO). S-BMO produced a microbiotadependent augmentation of lean body mass gain, changed bone morphology, and altered liver, muscle, and brain metabolism in ways indicative of a greater ability to utilize nutrients for anabolism. These effects were also documented in gnotobiotic piglets using the same consortium and Malawian diet. These preclinical models indicate a causal, microbiota-dependent relationship between S-BMO and growth promotion.
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