期刊
CELLULAR & MOLECULAR BIOLOGY LETTERS
卷 25, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s11658-020-00212-1
关键词
ER-stress; Angiogenesis; Hypoxia-reoxygenation injury; Ischemia; Cell fate determination; UPRmt
资金
- National Science Center [UMO-2015/17/B/NZ3/01485, 2015/18/E/NZ3/00687]
- NIH [P30 DK072482]
- Research Development Program from the CF Foundation [ROWE15R0]
During hypoxic conditions, cells undergo critical adaptive responses that include the up-regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein response (UPR). While their induced signaling pathways have many distinct targets, there are some important connections as well. Despite the extensive studies on both of these signaling pathways, the exact mechanisms involved that determine survival versus apoptosis remain largely unexplained and therefore beyond therapeutic control. Here we discuss the complex relationship between the HIF and UPR signaling pathways and the importance of understanding how these pathways differ between normal and cancer cell models.
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