期刊
CELL STEM CELL
卷 26, 期 3, 页码 309-329出版社
CELL PRESS
DOI: 10.1016/j.stem.2020.02.011
关键词
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资金
- National Institutes of Health [1UG3TR003148, 5UG3NS105703, T32 HL116273]
- Allen Distinguished Investigator Award [12879]
- Cedars-Sinai Board of Governors Regenerative Medicine Institute
- ALS Association
Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease modeling and have unlocked new possibilities for understanding the mechanisms governing human biology, physiology, and genetics. However, hiPSC-derivatives have traditionally been utilized in two-dimensional monocultures, in contrast to the multi-systemic interactions that influence cells in the body. We will discuss recent advances in generating more complex hiPSC-based systems using three-dimensional organoids, tissue-engineering, microfluidic organ-chips, and humanized animal systems. While hiPSC differentiation still requires optimization, these next-generation multi-lineage technologies can augment the biomedical researcher's toolkit and enable more realistic models of human tissue function.
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