期刊
CELL HOST & MICROBE
卷 27, 期 6, 页码 883-+出版社
CELL PRESS
DOI: 10.1016/j.chom.2020.04.017
关键词
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资金
- National Major Science & Technology Project for Control and Prevention of Major Infectious Diseases in China [2017ZX10204401, 2018ZX10301401, 2017ZX10103004, 2018ZX10305409]
- Innovation Fund for Medical Sciences [2016-I2M-1-014]
- National Natural Science Foundation of China [31670169, 31470267, 31701155]
- National Key Research and Development Program of China [2017YFC0908403, 2020YFA0707600]
- Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019PT310029]
- Strategic Priority CAS Project [XDB38000000]
- Chinese Academy of Sciences
- Beijing Advanced Innovation Center for Genomics (ICG)
The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2 infection have posed a severe threat to global public health. It is unclear how the human immune system responds to this infection. Here, we used metatranscriptomic sequencing to profile immune signatures in the bronchoalveolar lavage fluid of eight COVID-19 cases. The expression of proinflammatory genes, especially chemokines, was markedly elevated in COVID-19 cases compared to community-acquired pneumonia patients and healthy controls, suggesting that SARS-CoV-2 infection causes hypercytokinemia. Compared to SARS-CoV, which is thought to induce inadequate interferon (IFN) responses, SARS-CoV-2 robustly triggered expression of numerous IFN-stimulated genes (ISGs). These ISGs exhibit immunopathogenic potential, with overrepresentation of genes involved in inflammation. The transcriptome data was also used to estimate immune cell populations, revealing increases in activated dendritic cells and neutrophils. Collectively, these host responses to SARS-CoV-2 infection could further our understanding of disease pathogenesis and point toward antiviral strategies.
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