期刊
CELL HOST & MICROBE
卷 27, 期 6, 页码 863-869出版社
CELL PRESS
DOI: 10.1016/j.chom.2020.05.009
关键词
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资金
- National Science Foundation [DGE-1656518]
- NIH [T32AI007290]
- NIH/NIDA [DP1 DA04608902]
- 2019 Sentinel Pilot Project from the Bill & Melinda Gates Foundation
- Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Diseases [1016687]
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has had devastating global impacts and will continue to have dramatic effects on public health for years to come. A better understanding of the immune response to SARS-CoV-2 will be critical for the application and development of therapeutics. The degree to which the innate immune response confers protection or induces pathogenesis through a dysregulated immune response remains unclear. In this review, we discuss what is known about the role of the innate immune system during SARS-CoV-2 infection, suggest directions for future studies, and evaluate proposed COVID-19 immunomodulating therapeutics.
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