期刊
CELL
卷 181, 期 5, 页码 969-977出版社
CELL PRESS
DOI: 10.1016/j.cell.2020.04.042
关键词
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资金
- ERC [833247]
- Spinoza grant of the Netherlands Association for Scientific Research
- National Institutes of Health [R01AI145781]
- European Union [RIA2018CO-2514-PROTID]
SARS-CoV-2 infection is mild in the majority of individuals but progresses into severe pneumonia in a small proportion of patients. The increased susceptibility to severe disease in the elderly and individuals with co-morbidities argues for an initial defect in anti-viral host defense mechanisms. Long-term boosting of innate immune responses, also termed trained immunity,'' by certain live vaccines (BCG, oral polio vaccine, measles) induces heterologous protection against infections through epigenetic, transcriptional, and functional reprogramming of innate immune cells. We propose that induction of trained immunity by whole-microorganism vaccines may represent an important tool for reducing susceptibility to and severity of SARS-CoV-2.
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