期刊
CELL
卷 181, 期 5, 页码 1112-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2020.04.043
关键词
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资金
- NIH Human Microbiome Project (HMP) [1U54DE02378901, S10OD020141]
- Stanford Diabetes Research Center (SDRC) [P30DK116074]
- Australian Government Research Training Program (RTP) Scholarship
- Deanship of Scientific Research (DSR), King Abdulaziz University (KAU)
- Jeddah the Ministry of Education for Saudi Arabia
Acute physical activity leads to several changes in metabolic, cardiovascular, and immune pathways. Although studies have examined selected changes in these pathways, the system-wide molecular response to an acute bout of exercise has not been fully characterized. We performed longitudinal multi- omic profiling of plasma and peripheral blood mononuclear cells including metabolome, lipidome, immunome, proteome, and transcriptome from 36 well-characterized volunteers, before and after a controlled bout of symptomlimited exercise. Time-series analysis revealed thousands of molecular changes and an orchestrated choreography of biological processes involving energy metabolism, oxidative stress, inflammation, tissue repair, and growth factor response, as well as regulatory pathways. Most of these processes were dampened and some were reversed in insulin-resistant participants. Finally, we discovered biological pathways involved in cardiopulmonary exercise response and developed prediction models revealing potential resting bloodbased biomarkers of peak oxygen consumption.
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