期刊
CELL
卷 181, 期 2, 页码 250-269出版社
CELL PRESS
DOI: 10.1016/j.cell.2020.03.036
关键词
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资金
- NOMIS Foundation
- Keck Foundation
- NIH Pioneer award
- NIH [R01 AI114929]
The ability to maintain health, or recover to a healthy state after disease, is an active process involving distinct adaptation mechanisms coordinating interactions between all physiological systems of an organism. Studies over the past several decades have assumed the mechanisms of health and disease are essentially inter-changeable, focusing on the elucidation of the mechanisms of disease pathogenesis to enhance health, treat disease, and increase healthspan. Here, I propose that the evolved mechanisms of health are distinct from disease pathogenesis mechanisms and suggest that we develop an understanding of the biology of physiological health. In this Perspective, I provide a definition of, a conceptual framework for, and proposed mechanisms of physiological health to complement our understanding of disease and its treatment.
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