期刊
CELL
卷 166, 期 2, 页码 492-505出版社
CELL PRESS
DOI: 10.1016/j.cell.2016.06.044
关键词
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资金
- Japan Society for the Promotion of Sciences Research Abroad Fellowship
- Human Frontier Science Program long-term fellowship
- National Institutes of Health [R00GM100000]
- Austrian Science Fund
- DFG (SPP ADAPTOMICS)
- ERC (MAXMAP)
- ERC (IMMUNEMESIS)
- National Science Foundation [MCB 0929402, MCB 1122246]
The epigenome orchestrates genome accessibility, functionality, and three-dimensional structure. Because epigenetic variation can impact transcription and thus phenotypes, it may contribute to adaptation. Here, we report 1,107 high-quality single-base resolution methylomes and 1,203 transcriptomes from the 1001 Genomes collection of Arabidopsis thaliana. Although the genetic basis of methylation variation is highly complex, geographic origin is a major predictor of genome-wide DNA methylation levels and of altered gene expression caused by epialleles. Comparison to cistrome and epicistrome datasets identifies associations between transcription factor binding sites, methylation, nucleotide variation, and co-expression modules. Physical maps for nine of the most diverse genomes reveal how transposons and other structural variants shape the epigenome, with dramatic effects on immunity genes. The 1001 Epigenomes Project provides a comprehensive resource for understanding how variation in DNA methylation contributes to molecular and non-molecular phenotypes in natural populations of the most studied model plant.
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