Review on marine carbohydrate-based gold nanoparticles represented by alginate and chitosan for biomedical application

Gold nanoparticles (AuNPs) have been attracted considerable attention in cancer therapy, drug delivery and other applications due to their unique physical, chemical, and optical properties. Marine carbohydrates are important biological macromolecules that widely exist in marine algae and animals, such as alginate, carrageenan, porphyran, fucoidan, ulvan, agarose, and chitosan. Their excellent properties, such as biocompatibility, biodegradability and no irritation, make them widely used in biomedicine and nanomaterials fields. More importantly, they can be easily modified by functional groups, such as sulfation, acetylation, and carboxylation, to further extend their applications. The marine carbohydrates functionalized AuNPs can increase their biocompatibility and targeting in a green preparation method. Here, we review recent advances on marine carbohydrate-based AuNPs for cancer therapy, imaging, drug delivery and other biomedical fields. The topics of selective surface modification in different carbohydrates and further biomedical applications of AuNPs are also discussed.