期刊
CARBOHYDRATE POLYMERS
卷 236, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.116002
关键词
Cationic chitosan derivatives; Antifungals; Structural optimization strategy; Antifungal therapy
资金
- National Key R&D Program of China [2018YFC0311305, 2019YFD0900705]
- Key Research and Development Program of Shandong Province [2018GHY115017]
- Qingdao Applied Basic Research Project [19-6-2-34-cg]
- Science and technology program of Nantong [MS120170234]
The increasing resistance of pathogen fungi poses a global public concern. There are several limitations in current antifungals, including few available fungicides, severe toxicity of some fungicides, and drug resistance. Therefore, there is an urgent need to develop new antifungals with novel targets. Chitosan has been recognized as a potential antifungal substance due to its good biocompatibility, biodegradability, non-toxicity, and availability in abundance, but its applications are hampered by the low charge density results in low solubility at physiological pH. It is believed that enhancing the positive charge density of chitosan may be the most effective approach to improve both its solubility and antifungal activity. Hence, this review mainly focuses on the structural optimization strategy of cationic chitosan and the potential antifungal applications. This review also assesses and comments on the challenges, shortcomings, and prospect of cationic chitosan derivatives as antifungal therapy.
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