期刊
CARBOHYDRATE POLYMERS
卷 235, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.115937
关键词
Nanocrystal-embedded microparticles; Redispersibility; Aerodynamic performance; Maltodextrin; Glass transition
资金
- National Natural Science Foundation of China [81760715]
- Young Jinggang Scholar of Jiangxi [GAN201882]
- youth talent support program of Jiangxi University of traditional Chinese medicine [1141900605]
The objective of this study was to investigate the influence of inulin (IL) and maltodextrin (MD) as matrix formers on the physical properties of drug nanocrystal-embedded microparticles (NEM) during spray-drying and storage. The redispersibility, aerodynamic performance and phase behaviour of NEM/MD and NEM/IL stored at different water activity (a(w)) values were evaluated. NEM with 2 g/g (relative to the weight of drug) of IL and MD exhibited the excellent performance after spray-drying. The water activity significantly influenced the redispersibility and aerodynamic performance of NEM/MD and NEM/IL. The NEM/MD presented a higher T-g at all a(w) values than did NEM/IL. The moisture-induced collapse of the amorphous glassy matrix of IL and MD could be responsible for the poor redispersibility and aerodynamic performance of NEM/IL and NEM/MD, respectively. The NEM/MD exhibited better aerodynamic performance at high a(w) (0.528) than did NEM/IL. Therefore, MD could be an excellent matrix former for inhalable NEM.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据