期刊
CELL
卷 166, 期 5, 页码 1080-1081出版社
CELL PRESS
DOI: 10.1016/j.cell.2016.08.014
关键词
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资金
- NIGMS NIH HHS [R01 GM065997] Funding Source: Medline
Cullin-RING (CRL) and RING1-IBR-RING2 (RBR) are two distinct types of ubiquitin ligases. In this issue, Scott et al. show that CRLs activate the RBR enzyme ARIH1 to initiate ubiquitin chains on CRL substrates, thereby marking an unexpected and important advance in our understanding of both enzymes.
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