期刊
CANCER GENE THERAPY
卷 28, 期 1-2, 页码 33-41出版社
SPRINGERNATURE
DOI: 10.1038/s41417-020-0180-0
关键词
-
类别
资金
- Shaanxi Provincial Key R&D Program: General Project-Social Development Area [2017SF-016]
Recent studies have shown that the long non-coding RNA RHPN1-AS1 is up-regulated in ovarian cancer and promotes cell proliferation, migration, and invasion. It functions by sponging miR-665 and up-regulating Akt3 expression, indicating its oncogenic role in ovarian cancer progression and potential as a therapeutic target.
Recent efforts have revealed that long non-coding RNAs exert crucial roles in cancer initiation and progression. RHPN1-AS1 is a 2030 bp transcript from human chromosome 8q24, and involved in tumorigenesis in uveal melanoma and non-small cell lung cancer, but it remains unknown in ovarian cancer. This study focused on the role of RHPN1-AS1 in ovarian cancer and found that RHPN1-AS1 was up-regulated in ovarian cancer tissues and cell lines. Overexpression of RHPN1-AS1 promoted ovarian cancer cell proliferation, migration, and invasion. Mechanistically, overexpression of RHPN1-AS1 decreased the expression of miR-665 and subsequently promoted the expression of Akt3 at posttranscriptional level. Taken together, RHPN1-AS1 positively regulated the expression of Akt3 through sponging miR-665, and exerted an oncogenic role in ovarian cancer progression, and indicates that RHPN1-AS1 may be a potential therapeutic target in ovarian cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据