The Current Status of the Production and Supply of Gallium-68

Gallium-68 (Ga-68) is an important radionuclide due to its successful use in the clinic. Currently, Ga-68 is produced and supplied by using germanium-68/Gallium-68 (Ge-68/Ga-68) generator systems in the preclinical and clinical environments. Until recently, the supply of Ge-68/Ga-68 generators, specifically the good manufacturing practices (GMP) grade, had a long lead time (up to 18 months). This led researchers to investigate the cyclotron production of Ga-68 by using solid and liquid targets. This report summarizes an overview of the chemistry, coordination chemistry, and radiochemistry of Ga and the current status of manufacturing and supply of Ga-68 radionuclide.