期刊
CANCER AND METASTASIS REVIEWS
卷 39, 期 2, 页码 505-517出版社
SPRINGER
DOI: 10.1007/s10555-020-09899-2
关键词
Caveolae; Cancer; Mechanosensing; Mechanotransdcution; Membrane tension; EHD2
类别
资金
- Curie Institute, INSERM
- CNRS
- Agence Nationale de la Recherche [ANR-17-CE-0013, ANR-19-CE15]
- Institut National du Cancer [INCa PLBIO18-01 INVADOCAV]
- Fondation pour la Recherche Medicale (FRM) [SPF201909009115]
Caveolae are bulb-like invaginations made up of two essential structural proteins, caveolin-1 and cavins, which are abundantly present at the plasma membrane of vertebrate cells. Since their discovery more than 60 years ago, the function of caveolae has been mired in controversy. The last decade has seen the characterization of new caveolae components and regulators together with the discovery of additional cellular functions that have shed new light on these enigmatic structures. Early on, caveolae and/or caveolin-1 have been involved in the regulation of several parameters associated with cancer progression such as cell migration, metastasis, angiogenesis, or cell growth. These studies have revealed that caveolin-1 and more recently cavin-1 have a dual role with either a negative or a positive effect on most of these parameters. The recent discovery that caveolae can act as mechanosensors has sparked an array of new studies that have addressed the mechanobiology of caveolae in various cellular functions. This review summarizes the current knowledge on caveolae and their role in cancer development through their activity in membrane tension buffering. We propose that the role of caveolae in cancer has to be revisited through their response to the mechanical forces encountered by cancer cells during tumor mass development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据