期刊
CANCER AND METASTASIS REVIEWS
卷 39, 期 3, 页码 739-754出版社
SPRINGER
DOI: 10.1007/s10555-020-09868-9
关键词
Metastasis; Metastasis suppressor; KISS1; KISS1R; Dormancy; G protein-coupled receptor
类别
资金
- National Foundation for Cancer Research
- Susan G. Komen for the Cure [SAC110037]
- METAvivor Research and Support, Inc.
- USPHS-National Institutes of Health [CA87728, CA134981]
- National Cancer Institute [P30-CA168524]
- National Institutes of Health [GM103418]
- KUMC Biomedical Research Training Program
- Hall Family Professorship in MolecularMedicine
The significance of KISS1 goes beyond its original discovery as a metastasis suppressor. Its function as a neuropeptide involved in diverse physiologic processes is more well studied. Enthusiasm regarding KISS1 has cumulated in clinical trials in multiple fields related to reproduction and metabolism. But its cancer therapeutic space is unsettled. This review focuses on collating data from cancer and non-cancer fields in order to understand shared and disparate signaling that might inform clinical development in the cancer therapeutic and biomarker space. Research has focused on amino acid residues 68-121 (kisspeptin 54), binding to the KISS1 receptor and cellular responses. Evidence and counterevidence regarding this canonical pathway require closer look at the covariates so that the incredible potential of KISS1 can be realized.
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