4.5 Review

CDK7 inhibitors as anticancer drugs

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942

Georgina P. Sava et al.

ONCOGENE (2020)

Article Gastroenterology & Hepatology

Aberrant Super-Enhancer Landscape in Human Hepatocellular Carcinoma

Felice Ho-Ching Tsang et al.

HEPATOLOGY (2019)

Article Biochemistry & Molecular Biology

THZ1 reveals CDK7-dependent transcriptional addictions in pancreatic cancer

Ping Lu et al.

ONCOGENE (2019)

Article Multidisciplinary Sciences

Efficacy of the novel CDK7 inhibitor QS1189 in mantle cell lymphoma

Yun Jung Choi et al.

SCIENTIFIC REPORTS (2019)

Article Multidisciplinary Sciences

A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells

Chiara Ghezzi et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Small-molecule targeting of brachyury transcription factor addiction in chordoma

Tanaz Sharifnia et al.

NATURE MEDICINE (2019)

Review Medicine, Research & Experimental

Bromodomain and extra-terminal motif inhibitors: a review of preclinical and clinical advances in cancer therapy

Ali Alqahtani et al.

FUTURE SCIENCE OA (2019)

Article Biochemistry & Molecular Biology

Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype

Calla M. Olson et al.

CELL CHEMICAL BIOLOGY (2019)

Article Oncology

Are all cyclin-dependent kinases 4/6 inhibitors created equal?

Antonio Marra et al.

NPJ BREAST CANCER (2019)

Review Biochemistry & Molecular Biology

CDK9: a signaling hub for transcriptional control

Curtis W. Bacon et al.

TRANSCRIPTION-AUSTIN (2019)

Review Biochemistry & Molecular Biology

Therapeutic targeting of transcriptional cyclin-dependent kinases

Matthew D. Galbraith et al.

TRANSCRIPTION-AUSTIN (2019)

Article Dermatology

High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma

Philip Eliades et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

Article Oncology

ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment

Hetal Patel et al.

MOLECULAR CANCER THERAPEUTICS (2018)

Review Biochemistry & Molecular Biology

The essential and multifunctional TFIIH complex

Jenna K. Rimel et al.

PROTEIN SCIENCE (2018)

Article Biochemistry & Molecular Biology

Inhibition of cyclin-dependent kinase 7 suppresses human hepatocellular carcinoma by inducing apoptosis

Liqiang Zhong et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Article Oncology

CDK7 inhibition is a novel therapeutic strategy against GBM both in vitro and in vivo

Wei Meng et al.

CANCER MANAGEMENT AND RESEARCH (2018)

Review Oncology

Revisiting the role of ABC transporters in multidrug-resistant cancer

Robert W. Robey et al.

NATURE REVIEWS CANCER (2018)

Article Biochemistry & Molecular Biology

Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors

Yang Gao et al.

CELL CHEMICAL BIOLOGY (2018)

Review Pharmacology & Pharmacy

Inhibitors of cyclin-dependent kinases as cancer therapeutics

Steven R. Whittaker et al.

PHARMACOLOGY & THERAPEUTICS (2017)

Article Multidisciplinary Sciences

THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors

Florencia Cayrol et al.

NATURE COMMUNICATIONS (2017)

Article Cell Biology

Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications

Christopher C. Ebmeier et al.

CELL REPORTS (2017)

Review Oncology

A Review of Fulvestrant in Breast Cancer

Mark R. Nathan et al.

ONCOLOGY AND THERAPY (2017)

Article Oncology

Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma

Surya Nagaraja et al.

CANCER CELL (2017)

Review Biochemistry & Molecular Biology

Transcriptional Addiction in Cancer

James E. Bradner et al.

Article Biochemistry & Molecular Biology

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

Tinghu Zhang et al.

NATURE CHEMICAL BIOLOGY (2016)

Article Cell Biology

Structural and Functional Analysis of the Cdk13/Cyclin K Complex

Ann Katrin Greifenberg et al.

CELL REPORTS (2016)

Article Cell & Tissue Engineering

CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex

Aisha I. Abdullah et al.

STEM CELL REPORTS (2016)

Article Biochemistry & Molecular Biology

CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer

Yubao Wang et al.

Article Biochemistry & Molecular Biology

Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH

Jie Luo et al.

MOLECULAR CELL (2015)

Article Biochemistry & Molecular Biology

THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing

Kyle A. Nilson et al.

MOLECULAR CELL (2015)

Review Biotechnology & Applied Microbiology

The history and future of targeting cyclin-dependent kinases in cancer therapy

Uzma Asghar et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Article Biochemistry & Molecular Biology

CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

Edmond Chipumuro et al.

Article Multidisciplinary Sciences

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Nicholas Kwiatkowski et al.

NATURE (2014)

Article Multidisciplinary Sciences

Discovery and saturation analysis of cancer genes across 21 tumour types

Michael S. Lawrence et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

Kin28 regulates the transient association of Mediator with core promoters

Celia Jeronimo et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)

Article Multidisciplinary Sciences

The structure and substrate specificity of human Cdk12/Cyclin K

Christian A. Boesken et al.

NATURE COMMUNICATIONS (2014)

Review Genetics & Heredity

Control of Transcriptional Elongation

Hojoong Kwak et al.

ANNUAL REVIEW OF GENETICS, VOL 47 (2013)

Article Biochemistry & Molecular Biology

Super-Enhancers in the Control of Cell Identity and Disease

Denes Hnisz et al.

Editorial Material Cell Biology

The CDK-activating kinase Cdk7 Taking yes for an answer

Miriam Merzel Schachter et al.

CELL CYCLE (2013)

Article Biochemistry & Molecular Biology

A Cdk7-Cdk4 T-Loop Phosphorylation Cascade Promotes G1 Progression

Miriam Merzel Schachter et al.

MOLECULAR CELL (2013)

Article Multidisciplinary Sciences

Mutational landscape and significance across 12 major cancer types

Cyriac Kandoth et al.

NATURE (2013)

Article Multidisciplinary Sciences

ARCH domain of XPD, an anchoring platform for CAK that conditions TFIIH DNA repair and transcription activities

Wassim Abdulrahman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II

Stephane Larochelle et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Article Multidisciplinary Sciences

TFIIB dephosphorylation links transcription inhibition with the p53-dependent DNA damage response

Jayasha Shandilya et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process

Pierre Chymkowitch et al.

EMBO JOURNAL (2011)

Article Biochemistry & Molecular Biology

A novel PKC-ι inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma

Prajit Pillai et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2011)

Article Cell Biology

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1

Bartlomiej Bartkowiak et al.

GENES & DEVELOPMENT (2010)

Article Multidisciplinary Sciences

The landscape of somatic copy-number alteration across human cancers

Rameen Beroukhim et al.

NATURE (2010)

Article Cell Biology

p53 Research: The Past Thirty Years and the Next Thirty Years

David Lane et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Article Biochemistry & Molecular Biology

TFIIH Kinase Places Bivalent Marks on the Carboxy-Terminal Domain of RNA Polymerase II

Md. Sohail Akhtar et al.

MOLECULAR CELL (2009)

Article Biochemistry & Molecular Biology

Nucleotide excision repair driven by the dissociation of CAK from TFIIH

Frederic Coin et al.

MOLECULAR CELL (2008)

Article Biochemistry & Molecular Biology

Distinct Activation Pathways Confer Cyclin-Binding Specificity on Cdk1 and Cdk2 in Human Cells

Karl A. Merrick et al.

MOLECULAR CELL (2008)

Article Biochemistry & Molecular Biology

RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes

Kira Glover-Cutter et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)

Article Multidisciplinary Sciences

Serine-7 of the RNA polymerase IICTD is specifically required for snRNA gene expression

Sylvain Egloff et al.

SCIENCE (2007)

Article Cell Biology

Confirmation of a BRAF mutation-associated gene expression signature in melanoma

Peter Johansson et al.

PIGMENT CELL RESEARCH (2007)

Article Biochemistry & Molecular Biology

Differential regulation of estrogen-inducible proteolysis and transcription by the estrogen receptor α N terminus

CC Valley et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations

E Compe et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

The crystal structure of human CDK7 and its protein recognition properties

G Lolli et al.

STRUCTURE (2004)

Article Biochemistry & Molecular Biology

Selective regulation of vitamin D receptor-responsive genes by TFIIH

P Drané et al.

MOLECULAR CELL (2004)

Article Biochemistry & Molecular Biology

Microarray expression profiling in melanoma reveals a BRAF mutation signature

S Pavey et al.

ONCOGENE (2004)

Article Oncology

Phase II study of oral vinorelbine in first-line advanced breast cancer chemotherapy

G Freyer et al.

JOURNAL OF CLINICAL ONCOLOGY (2003)

Article Biochemistry & Molecular Biology

The cyclin H/cdk7/Mat1 kinase activity is regulated by CK2 phosphorylation of cyclin H

E Schneider et al.

ONCOGENE (2002)

Review Oncology

Tamoxifen ('Nolvadex'): a review

M Clemons et al.

CANCER TREATMENT REVIEWS (2002)

Article Multidisciplinary Sciences

TFIIH is negatively regulated by cdk8-containing mediator complexes

S Akoulitchev et al.

NATURE (2000)

Article Biochemistry & Molecular Biology

TFIIH interacts with the retinoic acid receptor γ and phosphorylates its AF-1-activating domain through cdk7

J Bastien et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)