期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 168, 期 6, 页码 730-733出版社
SPRINGER
DOI: 10.1007/s10517-020-04790-0
关键词
prenatal stress; ultrasound effect; autism spectrum disorder; autism model; rat offspring
We studied the possibility of developing an autism model based on chronic prenatal psychological stress caused by variable frequency ultrasound 20-45 kHz. The offspring of female rats stressed during pregnancy demonstrated reduced time of social contacts in the social interaction test, increased anxiety in the open-field test, and memory impairment in the Morris water maze test in comparison with the control (intact) rat offspring. We also found a reducing trend in the BDNF gene expression in the amygdala in males of the experimental group. The results showed the possibility of developing the animal autism model based on prenatal stress.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据