期刊
BULLETIN DU CANCER
卷 107, 期 7-8, 页码 813-822出版社
ELSEVIER MASSON, CORP OFF
DOI: 10.1016/j.bulcan.2020.04.009
关键词
Radiation therapy; Lymphopenia; Immunotherapy; Prognosis
类别
Radiation induced lymphopenia is frequent and can be severe and durable. Although lymphocytes hove long been known as highly radiosensitive cells, it is poorly characterized. Radiation-induced lymphopenia seems to affect lymphocyte subpopulations differently and seems to be influenced by radiation modalities. The depth and duration of lymphopenia depend on the location of the irradiation and the volumes of treatment. Importantly, radiation-induced lymphopenia has been associated with poorer prognosis in several tumor types. The knowledge about radiation-induced lymphopenia might lead to a rethinking of the modalities of radiotherapy and new approaches to restore lymphocytes counts.
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