期刊
BRITISH POULTRY SCIENCE
卷 61, 期 5, 页码 518-522出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00071668.2020.1759787
关键词
Eimeria maxima; IFN-gamma; coccidiosis; vaccine; immunology
资金
- National Natural Science Foundation of China [31872466]
- Discipline Development Grant from College of Animal Sciences FAFU [2018DK004]
- Project of Fujian Science and Technology Department [2019N0005]
1. Immune mapped protein-1 (IMP1) ofE. maximahas been identified as a vaccine antigen candidate forE. maximainfection. 2. In the current study, the N- and C-terminal derivative of EmIMP1 were expressed inE. coliand administered to chickens. The antibody response, cell-mediated immune (CMI) response and the protective efficacy of the protein vaccines againstE. maximachallenge were evaluated. 3. The results showed that C-terminal derivative of EmIMP1 vaccination could increase weight gain, reduce enteric lesions, and decrease faecal oocysts shedding. Moreover, the C-terminal derivative of EmIMP1 caused reasonable improvement in serum antibodies and the numbers of IFN-gamma producing peripheral blood mononuclear cells (PBMC), as compared to the control group. 4. This study demonstrated that the C-terminal derivative of EmIMP1 could be used as a potent immunogenic candidate in the development of subunit vaccines against E. maxima infection.
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