4.4 Article

Dietary inflammatory potential in relation to the gut microbiome: results from a cross-sectional study

期刊

BRITISH JOURNAL OF NUTRITION
卷 124, 期 9, 页码 931-942

出版社

CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114520001853

关键词

Diet; Inflammation; Gut microbiota; Cross-sectional studies; Circulating markers

资金

  1. University of Texas MD Anderson Cancer Center Duncan Family Institute for Cancer Prevention and Risk Assessment
  2. American Cancer Society [RSG-17-049-01-NEC]
  3. Cancer Prevention and Research Institute of Texas [RP170259]
  4. Chandler Cox Foundation
  5. National Cancer Institute Cancer Prevention Research Training Program [R25 CA056452, R25 CA057730]
  6. National Cancer Institute Cancer Center Support Grant [CCSG5P30 CA016672-37]

向作者/读者索取更多资源

Diet has direct and indirect effects on health through inflammation and the gut microbiome. We investigated total dietary inflammatory potential via the literature-derived index (Dietary Inflammatory Index (DII(R))) with gut microbiota diversity, composition and function. In cancer-free patient volunteers initially approached at colonoscopy and healthy volunteers recruited from the medical centre community, we assessed 16S ribosomal DNA in all subjects who provided dietary assessments and stool samples (n101) and the gut metagenome in a subset of patients with residual fasting blood samples (n34). Associations of energy-adjusted DII scores with microbial diversity and composition were examined using linear regression, permutational multivariate ANOVA and linear discriminant analysis. Spearman correlation was used to evaluate associations of species and pathways with DII and circulating inflammatory markers. Across DII levels,alpha- and beta-diversity did not significantly differ; however,Ruminococcus torques, Eubacterium nodatum, Acidaminococcus intestiniandClostridium leptumwere more abundant in the most pro-inflammatory diet group, whileAkkermansia muciniphilawas enriched in the most anti-inflammatory diet group. With adjustment for age and BMI,R. torques, E. nodatumandA. intestiniremained significantly associated with a more pro-inflammatory diet. In the metagenomic and fasting blood subset,A. intestiniwas correlated with circulating plasminogen activator inhibitor-1, a pro-inflammatory marker (rho = 0 center dot 40), but no associations remained significant upon correction for multiple testing. An index reflecting overall inflammatory potential of the diet was associated with specific microbes, but not overall diversity of the gut microbiome in our study. Findings from this preliminary study warrant further research in larger samples and prospective cohorts.

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