期刊
BMC GASTROENTEROLOGY
卷 20, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12876-020-01212-3
关键词
Gut microbiota; Diarrhea-predominant IBS; Short-chain fatty acids
资金
- National Natural Science Foundation of China [81970471]
Background Short-chain fatty acids (SCFAs) alteration have been reported in irritable bowel syndrome (IBS), but the results are conflicting. Our study aims to explore the alteration of SCFAs in patients with diarrhea-predominant IBS (IBS-D) and their potential role in the occurrence and development of IBS. Methods We recruited patients with IBS-D defined by Rome IV criteria and age-and-gender matched healthy controls (HCs). A headspace solid-phase microextraction gas chromatography-mass spectrometric (HS-SPME-GC-MS) method was developed for the analysis of acetic, propionic and butyric acid in feces and serum. Results Compared with HCs, the levels of the serum propionate (2.957 +/- 0.157 vs 2.843 +/- 0.098 mmol/L, P = 0.012) and butyrate (2.798 +/- 0.126 vs 2.697 +/- 0.077 mmol/L, P = 0.012) were significantly higher in IBS-D group. No significant differences were found among two groups with regard to the concentration of fecal acetate (4.953 +/- 1.065 vs 4.774 +/- 1.465 mg/g, P = 0.679), propionate (6.342 +/- 1.005 vs 6.282 +/- 1.077 mg/g, P = 0.868) and butyrate (2.984 +/- 0.512 vs 3.071 +/- 0.447 mg/g, P = 0.607). Conclusions Metabolites of gut microbiota, the propionic and butyric acid, are increased in patients with IBS-D in serum but not in feces. It suggests that propionic and butyric acid might be associated with the occurrence and development of IBS.
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