期刊
BIOORGANIC CHEMISTRY
卷 98, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2020.103763
关键词
Euphorbia esula; Jatrophane diterpenoids; Multidrug resistance (MDR); SARs
资金
- Natural Science Foundation of China [81722042, 81973195, 81973203]
- Guangdong Provincial Key Laboratory of Construction Foundation [2017B030314030]
- Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [2017BT01Y093]
Thirteen new jatrophane diterpenoids, euphoresulanes A-M (1-13), and seven known analogues (14-20) were isolated from the whole plants of Euphorbia esula. Their structures were elucidated by extensive spectroscopic analysis, and the absolute configurations of 1, 6, and 10 were confirmed by single crystal X-ray diffraction. Compounds 1-20 were screened for the multidrug resistance (MDR) reversal activity on P-glycoprotein (Pgp)-dependent cancer cell line HepG2/ADR, and 1, 2, 4, 6, and 8 exhibited comparable activity to the positive drugs. Euphoresulane H (8), the most active MDR modulator, could enhance the efficacy of anticancer drug adriamycin to ca. 33 folds at 5 mu M. The structure-activity relationship (SAR) study revealed that the acyloxy substitution at C-9 is essential to the activity and presence of H-2 was favorable.
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