期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 125, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2020.109997
关键词
RNA therapy; RNA drugs; Cancer immunotherapy; Clinical trials
资金
- National Natural Science Foundation of China [81541153, J18111211]
- Southern Science and Engineering Guangdong Laboratory Zhanjiang [ZJW-2019-07]
- Guangdong Provincial Science and Technology Department [2016A050503046, 2015A050502048, 2016B030309002]
- Public Service Platform of South China for RAMP
- D Marine Biomedicine Resources [GDMUK201808]
- Zhanjiang Science and Technology Plan [2017A06012]
- Group-type Special Supporting Project for Educational Talents in Universities [4SG19057G]
RNA therapy is a treatment that regulates cell proteins and cures diseases by affecting the metabolism of mRNAs in cells, which has cut a figure in the studies on various incurable illnesses like hereditary diseases, tumors, etc. In this review, we introduced the discovery and development of RNA therapy and discussed its classification, mechanisms, advantages, and challenges. Moreover, we highlighted how RNA therapy works in killing tumor cells as well as what progresses it has made in related researches. And the development of RNA anti-tumor drugs and the clinical trial process were also included.
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