期刊
BIOMATERIALS
卷 238, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2020.119834
关键词
Aggregation-induced emission (AIE); Multifunction; core@shell; Synergistic; Less is more
资金
- Research Grants Council of Hong Kong [C6009-17G, 16305518]
- Innovation and Technology Commission [ITC-CNERC14SC01, ITCPD/17-9]
- National Science Foundation of China [21788102, 81401458, 21705111]
- National Key Research and Development program of China [2018YFE0190200]
- Science and Technology Plan of Shenzhen [JCYJ20160229205601482, JCYJ20180507183832744]
Nanomaterials with integrated multiple imaging and therapeutic modalities possess great potentials in accurate cancer diagnostics and enhanced therapeutic efficacy. Traditional strategies for achieving multimodality nanoplatform through one by one combination of different modalities are challenged by the complicated structural design and fabrication as well as inherent incompatibility between different modalities. Herein, a novel strategy is presented to realize multimodal imaging and synergistic therapy using a class of simple silver core/AIE (aggregation-induced emission) shell nanoparticles. In addition to the intrinsic AIE fluorescence (FL) and metal-based computed tomography (CT) and radiation therapy (RT) properties, an extra functionality at the core/shell interface was identified to enable excellent photothermal (PT) and photoacoustic (PA) performance. As a result, five imaging and therapy modalities (FL, CT, PA, photothermal therapy (PTT), and RT) were achieved with a single structural unit for sensitive tumor imaging and effective therapy.
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